Debt and Interest- Additional Information (Detail) - USD ($)
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1 Months Ended |
12 Months Ended |
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Sep. 14, 2016 |
Feb. 13, 2014 |
Oct. 25, 2016 |
Sep. 30, 2016 |
Jun. 30, 2016 |
Feb. 29, 2016 |
Oct. 30, 2015 |
Aug. 31, 2012 |
Dec. 31, 2016 |
Dec. 31, 2015 |
Dec. 31, 2014 |
Jul. 31, 2016 |
Oct. 31, 2015 |
Sep. 18, 2015 |
Mar. 31, 2015 |
| Debt [Line Items] |
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| Term loan |
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$ 30,224,000
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$ 24,009,000
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| Warrant to purchase common stock |
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7.00
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| Warrant exercise price |
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$ 2,500
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$ 7.00
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| Debt Instrument, Interest Rate, Stated Percentage |
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39.00%
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| Debt Discount |
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$ 1,466,000
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314,000
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$ 0
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| Debt discount recorded |
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2,009,000
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835,000
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| Debt Instrument, Unamortized Discount (Premium), Net, Total |
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$ 400,000
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| Percentage of Cash Flow Pursuant to ASC 470 |
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10.00%
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| Fair Value Adjustment of Warrants |
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$ 1,039,000
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438,000
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0
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| Debt Related Commitment Fees and Debt Issuance Costs |
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1,032,000
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0
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0
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| Professional Fees |
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$ 0.2
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| Convertible Notes Payable, Current |
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$ 1,031,000
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0
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| Letter of Credit [Member] |
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| Debt [Line Items] |
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| Debt Instrument, Interest Rate, Stated Percentage |
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2.00%
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| Interest Expense, Debt |
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$ 11,000
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0
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0
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| Letters of Credit Outstanding, Amount |
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1,500,000
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| Warrant [Member] |
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| Debt [Line Items] |
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| Approximate fair value of the warrant |
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$ 300,000
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| Israel Discount Bank Of New York [Member] |
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| Debt [Line Items] |
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| Debt Instrument, Fee Amount |
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$ 15,000,000
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| Notes Payable |
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$ 14,900,000
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14,000,000
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| IDB Promissory Note Payable [Member] |
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| Debt [Line Items] |
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| Debt Instrument, Interest Rate, Stated Percentage |
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2.25%
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| Debt Instrument, Unused Borrowing Capacity, Amount |
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100,000
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| Debt Instrument, Periodic Payment |
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14,000,000
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| Debt Instrument, Fee Amount |
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15,000,000
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| Loan Agreement [Member] |
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| Debt [Line Items] |
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| Interest rate |
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The loan bore interest at a rate per annum equal to the greater of (i) 9.25% or (ii) 9.25% plus the sum of the prevailing prime rate minus 3.25%.
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| Maturity Date |
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Mar. 01, 2016
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| Interest payment term |
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The loan required interest-only payments for the initial 12 months and thereafter requires repayment of the principal balance with interest in 30 monthly installments.
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| Opus Credit Facility [Member] |
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| Debt [Line Items] |
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| Debt Instrument, Interest Rate, Stated Percentage |
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12.00%
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| Maturity Date |
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Sep. 14, 2018
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| Class Of Warrant Or Right Value Of Securities Called By Warrants Or Rights |
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$ 1,500,000
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| Class Of Warrant Or Right Exercise Price Percentage Of Warrants Or Rights |
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3.00%
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| Legal Fees |
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$ 25,000,000
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| Class Of Warrant Or Right Discount On Warrant |
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$ 2,000,000
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| Warrants and Rights Outstanding |
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7,000,000
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| NSC Notes Payable [Member] |
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| Debt [Line Items] |
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| Term loan |
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$ 3,608,000
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10,000,000
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| Debt Instrument, Interest Rate, Stated Percentage |
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8.00%
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| Debt discount recorded |
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$ 600,000
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| Debt Instrument, Face Amount |
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900,000
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| Interest Expense, Debt |
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$ 599,000
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$ 690,000
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0
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| Long-term Debt, Gross |
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$ 3,600,000
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| Notes Payable |
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$ 10,000,000
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| Debt Instrument, Term |
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10 years
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| Debt Instrument, Interest Rate, Effective Percentage |
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17.83%
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14.00%
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| Contingently Issuable Warrants Percentage |
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25.00%
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25.00%
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| Hercules Note Payble [Member] |
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| Debt [Line Items] |
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| Interest Expense, Debt |
[1] |
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$ 0
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$ 0
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845,000
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| Hercules Note Payble [Member] | Loan Agreement [Member] |
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| Debt [Line Items] |
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| Debt Instrument, Periodic Payment |
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14,000,000
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| Debt Instrument, Periodic Payment, Principal |
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13,200,000
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| Debt Instrument Term Charges |
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400,000
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| Debt Instrument, Fee Amount |
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300,000
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| Interest Expense, Debt |
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$ 100,000
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| Hercules Debt Agreement [Member] |
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| Debt [Line Items] |
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| Interest Expense, Debt |
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800,000
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| Accretion of debt discount |
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400,000
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| Hercules Debt Agreement [Member] | Warrant [Member] |
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| Debt [Line Items] |
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| Fair value of the warrant volatility |
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87.20%
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| Fair value of risk-free interest rate |
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1.10%
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| Hercules Debt Agreement [Member] | Loan Agreement [Member] |
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| Debt [Line Items] |
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| Term loan |
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$ 15,000,000
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| Received net proceeds |
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14,700,000
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| Subsequent private placement |
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$ 2,000,000
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| Warrant to purchase common stock |
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73,009
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| Warrant exercise price |
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$ 5.65
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| Charges on termination of the loan stated percentage |
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2.65%
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| Charges on termination of the loan, amount |
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$ 400,000
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| Debt Discount |
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$ 900,000
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| Interest rate for amortize loan discounts |
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12.30%
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| Fees Related To Loan Issuance Costs |
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$ 200,000
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| Helocyte Convertible Note One [Member] |
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| Debt [Line Items] |
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| Term loan |
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1,031,000
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0
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| Debt Instrument, Term |
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18 months
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| Proceeds from Issuance or Sale of Equity |
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$ 10,000,000
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| Class Of Warrant Or Right Value Of Securities Called By Warrants Or Rights |
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$ 400,000
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| Class Of Warrant Or Right Exercise Price Percentage Of Warrants Or Rights |
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110.00%
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| Legal Fees |
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$ 100,000
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| Helocyte Convertible Note One [Member] | Conversion One [Member] |
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| Debt [Line Items] |
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| Debt Instrument, Convertible, Terms of Conversion Feature |
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(a) the lowest price per share at which equity securities of Helocyte are sold in such sale less a 33% discount and (b) a per share price based on a pre-offering valuation of $50.0 million divided by the number of common shares outstanding on a fully-diluted basis.
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| Helocyte Convertible Note One [Member] | Conversion Two [Member] |
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| Debt [Line Items] |
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| Debt Instrument, Convertible, Terms of Conversion Feature |
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(a) a discount to the price per share being paid in the Sale of Helocyte equal to 33% or (b) a conversion price per share based on a pre-sale valuation of $50.0 million divided by the fully-diluted common stock of Helocyte immediately prior to the Sale of Helocyte (excluding the notes).
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| Helocyte Convertible Note One [Member] | Minimum [Member] |
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| Debt [Line Items] |
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| Debt Instrument, Interest Rate, Stated Percentage |
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5.00%
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| Helocyte Convertible Note One [Member] | Maximum [Member] |
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| Debt [Line Items] |
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| Debt Instrument, Interest Rate, Stated Percentage |
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8.00%
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| Avenue Convertible Note [Member] |
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| Debt [Line Items] |
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| Term loan |
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$ 200,000
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0
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| Subsequent private placement |
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$ 200,000
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| Debt Instrument, Term |
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18 months
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| Debt Related Commitment Fees and Debt Issuance Costs |
|
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$ 70,000
|
$ 0
|
$ 0
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| Debt Instrument, Convertible, Terms of Conversion Feature |
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(a) the lowest price per share at which equity securities of Avenue are sold in such sale less a 33% discount and (b) a per share price based on a pre-offering valuation of $30.0 million divided by the number of common shares outstanding on a fully-diluted basis.
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| Proceeds from Issuance or Sale of Equity |
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$ 10,000,000
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| Class Of Warrant Or Right Value Of Securities Called By Warrants Or Rights |
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10,000
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| Legal Fees |
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$ 44,000
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| Debt Instrument, Interest Rate, Stated Percentage,Current Year |
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5.00%
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| Debt Instrument, Interest Rate, Stated Percentage,After Twelve Month |
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8.00%
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| Net Proceeds From Issuance Of Private Placement After Paying Fees |
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$ 100,000
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| Payments for Other Fees |
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|
|
|
|
|
|
|
58,000
|
|
|
|
|
|
|
| Paymens For Placement Fee |
|
|
|
|
|
|
|
|
|
10,000
|
|
|
|
|
|
|
| Professional Fees |
|
|
|
|
|
|
|
|
|
4,000
|
|
|
|
|
|
|
| Convertible Notes Payable, Current |
|
|
|
|
|
|
|
|
|
$ 200,000
|
|
|
|
|
|
|
| Placement Fee Percentage |
|
|
|
|
|
|
|
|
|
10.00%
|
|
|
|
|
|
|
| Avenue Convertible Note [Member] | Minimum [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Debt [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Debt Instrument, Interest Rate, Stated Percentage |
|
|
|
|
|
|
|
|
|
5.00%
|
|
|
|
|
|
|
| Avenue Convertible Note [Member] | Maximum [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Debt [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Debt Instrument, Interest Rate, Stated Percentage |
|
|
|
|
|
|
|
|
|
8.00%
|
|
|
|
|
|
|
| Helocyte Convertible Note [Member] | Maximum [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Debt [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Debt Instrument, Face Amount |
|
|
|
|
|
|
|
|
|
$ 5,000,000
|
|
|
|
|
|
|
| Checkpoint [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Debt [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Debt Instrument, Unamortized Discount (Premium), Net, Total |
|
|
|
|
|
|
$ 300,000
|
|
|
|
|
|
|
|
|
|
| Long-term Debt, Fair Value |
|
|
|
|
|
|
200,000
|
|
|
|
|
|
|
|
|
|
| Fees Related To Loan Issuance Costs |
|
|
|
|
|
|
$ 2,800,000
|
|
|
|
|
|
|
|
|
|
| Checkpoint [Member] | NSC Notes Payable [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Debt [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Debt Related Commitment Fees and Debt Issuance Costs |
|
|
|
|
|
|
|
|
|
2,800,000
|
|
|
|
|
|
|
| Avenue [Member] | NSC Notes Payable [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Debt [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Debt Related Commitment Fees and Debt Issuance Costs |
|
|
|
|
|
|
|
|
|
3,000,000
|
|
|
|
|
|
|
| Warrant to NSC [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Debt [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Approximate fair value of the warrant |
|
|
|
|
|
|
|
$ 600,000
|
|
|
|
|
|
|
|
|
| Debt discount recorded |
|
|
|
|
|
|
|
|
|
|
|
|
|
$ 200,000
|
|
|
| Share-based Compensation Arrangement by Share-based Payment Award, Non-Option Equity Instruments, Granted |
|
|
|
|
|
|
|
139,592
|
|
|
|
|
|
|
|
|
| Share-based Compensation, Shares Authorized under Stock Option Plans, Exercise Price Range, Exercisable Options, Weighted Average Exercise Price |
|
|
|
$ 0.0001
|
|
|
|
$ 0.0001
|
|
|
|
|
|
|
|
|
| Share-based Compensation Arrangement by Share-based Payment Award, Award Vesting Period |
|
|
|
10 years
|
|
|
|
10 years
|
|
|
|
|
|
|
|
|
| Share-based Goods and Nonemployee Services Transaction, Valuation Method, Expected Term |
|
|
|
10 years
|
|
|
|
10 years
|
|
|
|
|
|
|
|
|
| Fair Value Adjustment of Warrants |
|
|
|
$ 800,000
|
|
|
|
$ 400,000
|
|
|
|
|
|
|
|
|
| Share Based Compensation Arrangement By Share Based Payment Award Non Option Equity Instruments Issued |
|
|
|
138,462
|
|
|
|
|
|
|
|
|
|
|
|
|
| Contingently Issuable Warrants issued in connection with NSC Note Avenue [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Debt [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Debt Instrument, Unamortized Discount (Premium), Net, Total |
|
|
|
|
|
|
|
|
|
100,000
|
|
|
|
$ 100,000
|
|
|
| Mustang [Member] | NSC Notes Payable [Member] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Debt [Line Items] |
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
|
| Debt Related Commitment Fees and Debt Issuance Costs |
|
|
|
|
|
|
|
|
|
$ 3,600,000
|
|
|
|
|
|
|
|
|