Annual report pursuant to Section 13 and 15(d)

Collaboration and Stock Purchase Agreements (Narrative) (Details)

v3.22.1
Collaboration and Stock Purchase Agreements (Narrative) (Details)
$ / shares in Units, $ in Thousands, shares in Millions
1 Months Ended 12 Months Ended
Oct. 06, 2021
USD ($)
Oct. 05, 2021
USD ($)
Feb. 24, 2021
USD ($)
Milestone
Feb. 08, 2019
USD ($)
$ / shares
shares
Nov. 12, 2018
Sep. 30, 2021
USD ($)
Dec. 31, 2021
USD ($)
Dec. 31, 2020
USD ($)
Collaboration revenue             $ 5,389 $ 0
Accumulated deficit             (547,463) (482,760)
Cash and cash equivalents             305,744 233,351
Cyprium [Member] | Sentynl Therapeutics, Inc [Member]                
Upfront fees payment     $ 8,000          
Payments of milestones     $ 12,000          
Percentage of ownership over any FDA priority review voucher     100.00%          
Number of net sales milestones | Milestone     5          
Number of development milestones | Milestone     2          
Collaboration revenue             $ 5,400 $ 0
Caelum [Member] | AstraZeneca [Member]                
Percentage of proceeds from option exercise   42.40%       42.40%    
Option exercise price   $ 150,000       $ 150,000    
Proceeds from option exercise   $ 56,900       $ 56,900    
Percentage of escrow holdback   10.00%            
Revenue from collaboration agreement   $ 148,600            
Maximum [Member] | Caelum [Member] | AstraZeneca [Member]                
Deconsolidation of consolidated partner company, contingent payment $ 350,000              
Revenue from collaboration agreement   $ 350,000            
SPMA [Member] | Avenue [Member] | InvaGen [Member]                
Sale of stock, ownership percentage after the transaction         33.30%      
FDA approval of the NDA [Member] | Cyprium [Member] | Sentynl Therapeutics, Inc [Member]                
Payments of milestones     $ 9,000          
Achievement of Certain Sales Milestones [Member] | Cyprium [Member] | Sentynl Therapeutics, Inc [Member]                
Payments of milestones     255,000          
Strategic Transaction, First Stage [Member] | SPMA [Member] | Avenue [Member] | InvaGen [Member]                
Sale of stock, number of shares issued | shares       5.8        
Stock offering, price per share | $ / shares       $ 6.00        
Sale of Stock, Consideration Received on Transaction       $ 35,000        
Sale of stock, ownership percentage after the transaction       33.30%        
Completion of Clinical Development Milestones [Member] | Cyprium [Member] | Sentynl Therapeutics, Inc [Member]                
Payments of milestones     $ 3,000