Annual report pursuant to Section 13 and 15(d)

Debt and Interest - Schedule of Interest Expenses for Debt Arrangements (Detail)

v3.8.0.1
Debt and Interest - Schedule of Interest Expenses for Debt Arrangements (Detail) - USD ($)
$ in Thousands
 12 Months Ended
Dec. 31, 2017
Dec. 31, 2016
Dec. 31, 2015
Debt [Line Items]      
Total Interest Expense and Financing Fee $ 5,860 $ 3,690 $ 1,484
LOC Fees [Member]      
Debt [Line Items]      
Interest 36 11 0
Interest and Debt Expense 36 11 0
IDB Note [Member]      
Debt [Line Items]      
Interest 340 328 314
Amortization of fees 0 1 5
Interest and Debt Expense 340 329 319
NSC Debt [Member]      
Debt [Line Items]      
Interest 147 599 690
Amortization of fees 201 1,270 309
Interest and Debt Expense 348 1,869 999
2017 Subordinated Note [Member]      
Debt [Line Items]      
Interest 2,234 0 0
Amortization of fees 76 0 0
Interest and Debt Expense 2,310 0 0
Ovamed [Member]      
Debt [Line Items]      
Interest 0 0 166
Interest and Debt Expense 0 0 166
Helocyte Convertible Note [Member]      
Debt [Line Items]      
Interest 261 61 0
Financing fee 1 962 0
Interest and Debt Expense 262 1,023 0
Opus Credit Facility [Member]      
Debt [Line Items]      
Interest 1,087 192 0
Amortization of fees 1,037 195 0
Interest and Debt Expense 2,124 387 0
Avenue Convertible Note [Member]      
Debt [Line Items]      
Interest 5 0 0
Financing fee 3 70 0
Interest and Debt Expense 8 70 0
Caelum Convertible Note [Member]      
Debt [Line Items]      
Interest 265 0 0
Financing fee 100 0 0
Interest and Debt Expense 365 0 0
Falk CSR [Member]      
Debt [Line Items]      
Interest 64 0 0
Interest and Debt Expense 64 0 0
D&O Insurance [Member]      
Debt [Line Items]      
Interest 3 1 0
Interest and Debt Expense $ 3 $ 1 $ 0