Quarterly report pursuant to Section 13 or 15(d)

Collaboration and Stock Purchase Agreements (Narrative) (Details)

v3.21.2
Collaboration and Stock Purchase Agreements (Narrative) (Details)
$ / shares in Units, $ in Thousands, shares in Millions
3 Months Ended 9 Months Ended 12 Months Ended
Oct. 06, 2021
USD ($)
Feb. 24, 2021
USD ($)
Milestone
Feb. 08, 2019
USD ($)
$ / shares
shares
Sep. 30, 2021
USD ($)
Sep. 30, 2020
USD ($)
Sep. 30, 2021
USD ($)
Sep. 30, 2020
USD ($)
Dec. 31, 2020
USD ($)
Collaboration revenue       $ 1,446 $ 0 $ 4,646 $ 0  
Accumulated deficit       (515,898)   (515,898)   $ (482,760)
Cash and cash equivalents       252,721 $ 218,389 252,721 $ 218,389 233,351
Cyprium [Member] | Sentynl Therapeutics, Inc [Member]                
Upfront fees payment   $ 8,000            
Payments of milestones   $ 12,000            
Percentage of ownership over any FDA priority review voucher   100.00%            
Number of net sales milestones | Milestone   5            
Number of development milestones | Milestone   2            
Collaboration revenue       1,400   4,600   $ 0
Avenue [Member]                
Accumulated deficit       76,100   76,100    
Cash and cash equivalents       $ 600   $ 600    
SPMA [Member] | Minimum [Member] | Avenue [Member] | InvaGen [Member]                
Percentage of common shares acquired in the Stock Purchase Transaction for the rights to exist     75.00%          
FDA approval of the NDA [Member] | Cyprium [Member] | Sentynl Therapeutics, Inc [Member]                
Payments of milestones   $ 9,000            
Achievement of Certain Sales Milestones [Member] | Maximum [Member] | Cyprium [Member] | Sentynl Therapeutics, Inc [Member]                
Payments of milestones   255,000            
Strategic Transaction, First Stage [Member] | SPMA [Member] | Avenue [Member] | InvaGen [Member]                
Sale of stock, number of shares issued | shares     5.8          
Stock offering, price per share | $ / shares     $ 6.00          
Sale of Stock, Consideration Received on Transaction     $ 35,000          
Sale of stock, ownership percentage after the transaction     33.30%          
Strategic Transaction, Second Stage [Member] | SPMA [Member] | Avenue [Member] | InvaGen [Member]                
Sale of Stock, Consideration Received on Transaction     $ 180,000          
Completion of Clinical Development Milestones [Member] | Cyprium [Member] | Sentynl Therapeutics, Inc [Member]                
Payments of milestones   $ 3,000            
Subsequent Events [Member] | Caelum [Member] | AstraZeneca [Member]                
Deconsolidation of consolidated partner company, upfront payment $ 150,000              
Deconsolidation of consolidated partner company, contingent payment 350,000              
Subsequent Events [Member] | Maximum [Member] | Caelum [Member] | AstraZeneca [Member]                
Deconsolidation of consolidated partner company, contingent payment $ 350,000