Annual report pursuant to Section 13 and 15(d)

Fair Value Measurements - Changes in Fair Value of Financial Instruments (Detail)

v3.19.1
Fair Value Measurements - Changes in Fair Value of Financial Instruments (Detail) - USD ($)
$ in Thousands
12 Months Ended
Dec. 31, 2018
Dec. 31, 2017
Fair Value, Assets Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]    
Balance $ 21,833 $ 20,941
Payment of convertible note (4,408)  
Disposal of National (5,375)  
Additions during the period   9,914
Conversion into common shares   (1,064)
Loss on write off investment 0 250
Change in fair value of investments (1,390) 226
Change in fair value of convertible notes (437) 457
Change in fair value of derivative liabilities 682 (8,391)
Balance 10,905 21,833
Helocyte [Member]    
Fair Value, Assets Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]    
Balance 4,700 4,487
Payment of convertible note (4,408)  
Disposal of National 0  
Additions during the period   0
Conversion into common shares   0
Loss on write off investment   0
Change in fair value of investments 0 0
Change in fair value of convertible notes (292) 213
Change in fair value of derivative liabilities 0 0
Balance 0 4,700
Avenue [Member]    
Fair Value, Assets Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]    
Balance 0 200
Additions during the period   0
Conversion into common shares   (299)
Loss on write off investment   0
Change in fair value of investments   0
Change in fair value of convertible notes   99
Change in fair value of derivative liabilities   0
Balance   0
Caelum Convertible Notes [Member]    
Fair Value, Assets Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]    
Balance 10,059 0
Payment of convertible note 0  
Disposal of National 0  
Additions during the period   9,914
Conversion into common shares   0
Loss on write off investment   0
Change in fair value of investments 0 0
Change in fair value of convertible notes (145) 145
Change in fair value of derivative liabilities 0 0
Balance 9,914 10,059
Warrants National [Member]    
Fair Value, Assets Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]    
Balance [1] 5,597 14,673
Payment of convertible note [1] 0  
Disposal of National [1] (5,597)  
Additions during the period [1]   0
Conversion into common shares [1]   (765)
Loss on write off investment [1]   0
Change in fair value of investments [1] 0 0
Change in fair value of convertible notes [1] 0 0
Change in fair value of derivative liabilities [1] 0 (8,311)
Balance [1] 0 5,597
Warrant liabilities [Member]    
Fair Value, Assets Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]    
Balance 87 167
Payment of convertible note 0  
Disposal of National 222  
Additions during the period   0
Conversion into common shares   0
Loss on write off investment   0
Change in fair value of investments 0 0
Change in fair value of convertible notes 0 0
Change in fair value of derivative liabilities 682 (80)
Balance 991 87
Investment In Laser Device [Member]    
Fair Value, Assets Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]    
Balance 0 250
Additions during the period   0
Conversion into common shares   0
Loss on write off investment   (250)
Change in fair value of investments   0
Change in fair value of convertible notes   0
Change in fair value of derivative liabilities   0
Balance   0
Investment In Origo [Member]    
Fair Value, Assets Measured on Recurring Basis, Unobservable Input Reconciliation [Line Items]    
Balance 1,390 1,164
Payment of convertible note 0  
Disposal of National 0  
Additions during the period   0
Conversion into common shares   0
Loss on write off investment   0
Change in fair value of investments (1,390) 226
Change in fair value of convertible notes 0 0
Change in fair value of derivative liabilities 0 0
Balance $ 0 $ 1,390
[1] Note 1: Warrants issued and issuable related to National