Quarterly report pursuant to Section 13 or 15(d)

Accrued Expenses and Other Long-Term Liabilities - Additional Information (Detail)

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Accrued Expenses and Other Long-Term Liabilities - Additional Information (Detail) (USD $)
 3 Months Ended
Mar. 31, 2014
Mar. 31, 2013
Dec. 31, 2013
Schedule Accrued Expenses And Other Long-Term Liabilities [Line Items]      
Payments for Rent $ 400,000    
Rental Income, Nonoperating 100,000    
Operating Leases, Rent Expense 700,000    
Impairment of Long-Lived Assets Held-for-use 300,000    
Other Accrued Liabilities Current 185,000   192,000
Asset Retirement Obligation, Accretion Expense 37,000 33,000  
Operating Leases, Rent Expense, Sublease Rentals 100,000    
Ovamed Manufacturing Rights [Member]
      
Schedule Accrued Expenses And Other Long-Term Liabilities [Line Items]      
Other Accrued Liabilities Current 500,000    
Other Accrued Liabilities, Noncurrent 716,000    
Woburn MA facility [Member]
      
Schedule Accrued Expenses And Other Long-Term Liabilities [Line Items]      
Lease Expiration Date Feb. 28, 2018    
Lease Expiration Period 2018    
New York NY Office Space [Member]
      
Schedule Accrued Expenses And Other Long-Term Liabilities [Line Items]      
Lease Expiration Date May 31, 2016    
Lease Expiration Period 2016    
Ovamed [Member]
      
Schedule Accrued Expenses And Other Long-Term Liabilities [Line Items]      
Other Liabilities Related To Manufacturing Rights 1,500,000    
Lease Agreements [Member]
      
Schedule Accrued Expenses And Other Long-Term Liabilities [Line Items]      
Other Research and Development Expense 800,000    
Chief Medical Officer [Member]
      
Schedule Accrued Expenses And Other Long-Term Liabilities [Line Items]      
Severance Costs 400,000    
Payments for Postemployment Benefits $ 1,000,000