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Debt- Additional Information (Detail) (USD $)
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1 Months Ended | 12 Months Ended | 90 Months Ended | 12 Months Ended | 12 Months Ended | 12 Months Ended | 1 Months Ended | 12 Months Ended | 1 Months Ended | 12 Months Ended | 1 Months Ended | 12 Months Ended | 1 Months Ended | 0 Months Ended | |||||||||||||||||
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Aug. 31, 2012
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Sep. 30, 2010
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Dec. 31, 2013
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Dec. 31, 2012
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Dec. 31, 2011
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Dec. 31, 2010
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Dec. 31, 2013
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Aug. 16, 2012
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Dec. 31, 2013
Series A [Member]
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Dec. 31, 2012
Series A [Member]
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Dec. 31, 2011
Series A [Member]
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Dec. 31, 2010
Series A [Member]
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Dec. 31, 2009
PCP Promissory Notes [Member]
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Dec. 31, 2010
PCP Promissory Notes [Member]
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Dec. 31, 2008
2008 Senior Convertible Notes [Member]
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Dec. 31, 2009
2009 Senior Convertible Notes [Member]
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Dec. 31, 2013
Senior Convertible Notes [Member]
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Dec. 31, 2010
Senior Convertible Notes [Member]
Series A [Member]
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Jan. 31, 2010
Related Party Notes [Member]
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Sep. 30, 2008
Related Party Notes [Member]
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Dec. 31, 2010
Related Party Notes [Member]
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Dec. 31, 2013
Related Party Notes [Member]
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Feb. 05, 2010
Related Party Notes [Member]
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Jan. 31, 2010
Related Party Notes [Member]
Series A Common Stock [Member]
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Dec. 31, 2010
Related Party Notes [Member]
Series A Common Stock [Member]
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Dec. 31, 2009
Warrant [Member]
PCP Promissory Notes [Member]
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Aug. 31, 2012
Hercules Debt Agreement [Member]
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Dec. 31, 2013
Hercules Debt Agreement [Member]
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Dec. 31, 2012
Hercules Debt Agreement [Member]
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Aug. 31, 2012
Hercules Debt Agreement [Member]
Warrant [Member]
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Jan. 07, 2011
Asphelia Asset Purchase [Member]
PCP Promissory Notes [Member]
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| Debt [Line Items] | |||||||||||||||||||||||||||||||
| Term loan | $ 15,000,000 | ||||||||||||||||||||||||||||||
| Received net proceeds | 570,000 | 14,700,000 | 750,000 | ||||||||||||||||||||||||||||
| Subsequent private placement | 2,000,000 | ||||||||||||||||||||||||||||||
| Warrant to purchase common stock | 20,000 | 27,175 | 73,009 | ||||||||||||||||||||||||||||
| Warrant exercise price | 5.72 | 5.65 | |||||||||||||||||||||||||||||
| Deduction rate on loan bears interest at a rate per annum | 3.25% | ||||||||||||||||||||||||||||||
| Loan bears interest at a rate per annum | 10.00% | 8.00% | 8.00% | 8.00% | 9.25% | 10.00% | |||||||||||||||||||||||||
| Interest rate | interest at a rate per annum equal to the greater of (i) 9.25% or (ii) 9.25% plus the sum of the prevailing prime rate minus 3.25% | ||||||||||||||||||||||||||||||
| Maturity Date | Mar. 01, 2016 | ||||||||||||||||||||||||||||||
| Interest payment term | interest-only payments for the initial 12 months and thereafter requires repayment of the principal balance with interest in 30 monthly installments. | ||||||||||||||||||||||||||||||
| Charges on termination of the loan stated percentage | 2.65% | ||||||||||||||||||||||||||||||
| Fair value of the warrant volatility | 104.51% | 87.20% | |||||||||||||||||||||||||||||
| Fair value of risk-free interest rate | 1.06% | 1.10% | |||||||||||||||||||||||||||||
| Approximate fair value of the warrant | 323,000 | ||||||||||||||||||||||||||||||
| Charges on termination of the loan, amount | 398,000 | ||||||||||||||||||||||||||||||
| Fees related to the loan agreement | 800,000 | 218,000 | |||||||||||||||||||||||||||||
| Debt Discount | 700,000 | 939,000 | |||||||||||||||||||||||||||||
| Interest rate for amortize loan discounts | 12.30% | ||||||||||||||||||||||||||||||
| Interest expenses accretion of debt discounts | 381,000 | 123,000 | |||||||||||||||||||||||||||||
| Interest expense related to the Hercules loan | 1,923,000 | 670,000 | 74,000 | 5,876,000 | 1,767,000 | 609,000 | |||||||||||||||||||||||||
| Current portion of note payable | 6,203,000 | 1,799,000 | 6,203,000 | 6,203,000 | |||||||||||||||||||||||||||
| Non current portion of notes payable | 7,017,000 | 12,386,000 | 7,017,000 | 7,017,000 | |||||||||||||||||||||||||||
| Debt discount recorded | 100,000 | 434,000 | |||||||||||||||||||||||||||||
| 2014 | 6,203,000 | 6,203,000 | |||||||||||||||||||||||||||||
| 2015 | 6,866,000 | 6,866,000 | |||||||||||||||||||||||||||||
| 2016 | 587,000 | 587,000 | |||||||||||||||||||||||||||||
| Common stock conversion price equal to lowest price paid by investors | 100.00% | 75.00% | |||||||||||||||||||||||||||||
| Qualified equity financing amount | 10,000,000 | ||||||||||||||||||||||||||||||
| Related party notes, principal and accrued interest | 300,000 | 1,600,000 | |||||||||||||||||||||||||||||
| Convertible Preferred stock number of preferred stock converted into common stock | 36,194 | 273,046 | |||||||||||||||||||||||||||||
| Share per price | $ 5.87 | $ 8.39 | $ 5.87 | ||||||||||||||||||||||||||||
| Repaid the principal amount of accrued interest | 600,000 | ||||||||||||||||||||||||||||||
| Increase Warrants pursuant to an anti-dilution | 5,090,171 | 3,371,161 | 10,206,543 | 0 | 0 | 3,796,733 | 40,787 | ||||||||||||||||||||||||
| Cash Commissions percentage of gross proceeds | 2.00% | ||||||||||||||||||||||||||||||
| Cash proceeds from 2008 Senior Convertible Notes | 4,100,000 | ||||||||||||||||||||||||||||||
| Cash proceeds from Senior Convertible Notes | 3,500,000 | ||||||||||||||||||||||||||||||
| Repayment Premium, Percentage | 42.90% | ||||||||||||||||||||||||||||||
| Principal and accrued interest total | 8,600,000 | ||||||||||||||||||||||||||||||
| Repayment Premium | $ 600,000 | ||||||||||||||||||||||||||||||
| Senior convertible notes converted to shares | 1,464,479 | ||||||||||||||||||||||||||||||
| Commission as percentage of gross proceeds | 7.00% | ||||||||||||||||||||||||||||||
| Debt Conversion, Converted Instrument, Expiration or Due Date | Feb. 20, 2009 | ||||||||||||||||||||||||||||||