TSO - Additional Information (Detail)
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1 Months Ended | 3 Months Ended | 6 Months Ended | 84 Months Ended | 1 Months Ended | 3 Months Ended | 6 Months Ended | |||||||||||
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Feb. 22, 2013
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Jun. 30, 2013
USD ($)
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Jun. 30, 2012
USD ($)
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Jun. 30, 2013
USD ($)
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Jun. 30, 2012
USD ($)
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Jun. 30, 2013
USD ($)
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Feb. 22, 2013
Joint Ownership and Exclusive License Agreement Fu Berlin [Member]
USD ($)
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Feb. 22, 2013
Joint Ownership and Exclusive License Agreement Fu Berlin [Member]
EUR (€)
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Feb. 22, 2013
Joint Ownership and Exclusive License Agreement Fu Berlin [Member]
Minimum [Member]
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Feb. 22, 2013
Joint Ownership and Exclusive License Agreement Fu Berlin [Member]
Maximum [Member]
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Feb. 22, 2013
License and Sublicense Agreement with Ovamed GmbH [Member]
Minimum [Member]
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Feb. 22, 2013
License and Sublicense Agreement with Ovamed GmbH [Member]
Maximum [Member]
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Feb. 22, 2013
License and Sublicense Agreement with Ovamed GmbH [Member]
Letter Agreement [Member]
USD ($)
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Feb. 22, 2013
License and Sublicense Agreement with Ovamed GmbH [Member]
Letter Agreement [Member]
EUR (€)
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Feb. 22, 2013
Research and Development Arrangement [Member]
USD ($)
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Feb. 22, 2013
Research and Development Arrangement [Member]
EUR (€)
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Jun. 30, 2013
Research and Development Arrangement [Member]
USD ($)
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Jun. 30, 2013
Research and Development Arrangement [Member]
USD ($)
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Long-term Purchase Commitment [Line Items] | ||||||||||||||||||
Expected project duration under research agreement | 4 years | 4 years | ||||||||||||||||
Research and development expense | $ 7,795,000 | $ 4,525,000 | $ 13,769,000 | $ 9,116,000 | $ 55,778,000 | $ 853,000 | € 648,000 | $ 52,700 | $ 75,000 | |||||||||
Written notice period under research agreement termination | 3 months | 3 months | ||||||||||||||||
Potential milestone payments based primarily on the achievement of clinical development and regulatory milestones | 4,982,000 | 3,830,000 | ||||||||||||||||
Percentage of royalty on net sales of products range | 1.00% | 2.50% | 1.00% | 2.50% | ||||||||||||||
Notice period to cure termination due to breach | 60 days | |||||||||||||||||
Period of notice for termination of Joint Ownership and exclusive license agreement | 60 days | |||||||||||||||||
Period of Written notice for termination of Joint Ownership and exclusive license agreement | 180 days | |||||||||||||||||
Maximum potential payment based on achievement of regulatory milestones | $ 1,333,000 | € 1,025,000 | ||||||||||||||||
Right Interest in Joint Intellectual Property | 10.00% |