Annual report pursuant to Section 13 and 15(d)

Stockholders' Equity (Narrative) (Details)

v3.23.1
Stockholders' Equity (Narrative) (Details) - USD ($)
$ in Thousands
12 Months Ended
Jan. 01, 2022
Jan. 01, 2021
Dec. 31, 2022
Dec. 31, 2021
Dec. 31, 2020
Dec. 31, 2015
Aug. 27, 2020
Dec. 31, 2016
Dec. 31, 2013
Dec. 31, 2007
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                    
Common Stock, shares authorized     200,000,000 170,000,000            
Stock-based compensation expense     $ 22,987 $ 19,486            
Stock options, unrecognized compensation expense     $ 100              
Stock based compensation, vesting period     10 years              
Journey                    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                    
Stock-based compensation expense     $ 4,425 2,466            
Consulting Agreements [Member]                    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                    
Warrants issued     100,000              
Oaktree Note [Member]                    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                    
Warrants issued             1,749,450      
2007 and 2013 Stock Incentive Plan [Member]                    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                    
Share based compensation, number of shares granted     21,110,948              
Stock based compensation, shares available for issuance     889,052              
2013 Stock Incentive Plan [Member]                    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                    
Stock based compensation, number of shares authorized           16,000,000     2,300,000  
Share based compensation, additional shares authorized     3,000,000     7,700,000        
2012 Employee Stock Purchase Plan [Member]                    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                    
Stock-based compensation expense     $ 100 100            
Predetermined fair value percentage during offering period     85.00%              
Shares purchased in connection with the ESPP offering     961,898              
Number of shares available for future issuance     38,102              
Long-term Incentive Plan [Member]                    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                    
Stock-based compensation expense       5,300 $ 3,800          
Fair value of stock granted     $ 2,800 $ 3,300            
LTIP, Percentage of outstanding shares     1.00%              
Long-Term Incentive Program condition, increase in market capitalization     $ 100,000              
Maximum | 2007 and 2013 Stock Incentive Plan [Member]                    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                    
Stock based compensation, shares available for issuance               22,000,000    
Maximum | 2007 Stock Incentive Plan [Member]                    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                    
Stock based compensation, number of shares authorized                   6,000,000
Chief Executive Officer (Dr. Rosenwald) [Member] | Long-term Incentive Plan [Member]                    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                    
Number of shares Granted 1,102,986 1,102,986                
Executive Vice President (Mr. Weiss) [Member] | Long-term Incentive Plan [Member]                    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                    
Number of shares Granted 1,030,339 1,030,339                
Employees and Non-Employees [Member]                    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                    
Number of shares Granted     1,600,000 1,400,000            
Research and Development Expense [Member]                    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                    
Stock-based compensation expense     $ 4,400 $ 4,300            
General and Administrative Expense [Member]                    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                    
Stock-based compensation expense     18,500 15,200            
Restricted Stock Awards and Restricted Stock Units [Member]                    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                    
Stock-based compensation expense     21,900 19,500            
Fair value of stock granted     7,300 $ 3,500            
Restricted Stock [Member]                    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                    
Unrecognized compensation expense for awards other than options     $ 16,300              
Number of shares Granted     3,755,972 2,330,678            
Stock based compensation, vesting period     2 years 4 months 24 days              
Fair value of stock granted     $ 7,000 $ 7,400            
Restricted Stock [Member] | Executives and Directors [Member]                    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                    
Number of shares Granted     3,800,000 2,300,000            
Restricted Stock [Member] | Non-Employee Directors [Member]                    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                    
Deferred compensation plan, shares issued     330,000 230,000            
Restricted Stock Units (RSUs) [Member]                    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                    
Unrecognized compensation expense for awards other than options     $ 1,500              
Number of shares Granted     1,604,945 1,405,842            
Stock based compensation, vesting period     1 year 1 month 6 days              
Fair value of stock granted     $ 2,100 $ 5,500            
Warrants to Purchase Common Stock [Member]                    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                    
Unrecognized compensation expense for awards other than options     $ 0              
Performance-based Awards [Member]                    
Share-based Compensation Arrangement by Share-based Payment Award [Line Items]                    
Number of shares Granted     100,000