Annual report pursuant to Section 13 and 15(d)

Debt (Details Textual)

v2.4.0.6
Debt (Details Textual) (USD $)
1 Months Ended 12 Months Ended 78 Months Ended 0 Months Ended 12 Months Ended 1 Months Ended 12 Months Ended 12 Months Ended 1 Months Ended 12 Months Ended 1 Months Ended 12 Months Ended 0 Months Ended 12 Months Ended
Aug. 31, 2012
Sep. 30, 2010
Dec. 31, 2012
Dec. 31, 2011
Dec. 31, 2010
Dec. 31, 2012
Aug. 16, 2012
Jan. 07, 2011
Asphelia Asset Purchase [Member]
Dec. 31, 2010
Series A [Member]
Dec. 31, 2012
Warrants [Member]
Dec. 31, 2011
Warrants [Member]
Dec. 31, 2010
Warrants [Member]
Aug. 31, 2012
Hercules debt agreement [Member]
Dec. 31, 2012
Hercules debt agreement [Member]
Installment
Dec. 31, 2012
Hercules debt agreement [Member]
Estimate of fair value, fair value disclosure [Member]
Dec. 31, 2012
Hercules debt agreement [Member]
Warrants [Member]
Feb. 28, 2010
Related Party Notes [Member]
Jan. 31, 2010
Related Party Notes [Member]
Jul. 31, 2009
Related Party Notes [Member]
Sep. 30, 2008
Related Party Notes [Member]
Dec. 31, 2012
Related Party Notes [Member]
Dec. 31, 2010
Related Party Notes [Member]
Jan. 31, 2010
Related Party Notes [Member]
Series A Common Stock [Member]
Dec. 31, 2012
Related Party Notes [Member]
Series A Common Stock [Member]
Dec. 31, 2012
Related Party Notes [Member]
Individual stockholder and Trust [Member]
Dec. 31, 2012
Related Party Notes [Member]
Stockholders Family Members [Member]
Dec. 31, 2012
Related Party Notes [Member]
Payable to PBS [Member]
Dec. 31, 2009
PCP Promissory Notes [Member]
Dec. 31, 2010
PCP Promissory Notes [Member]
Jan. 07, 2011
PCP Promissory Notes [Member]
Asphelia Asset Purchase [Member]
Dec. 31, 2009
PCP Promissory Notes [Member]
Warrants [Member]
Dec. 31, 2012
2008 Senior Convertible Notes [Member]
Dec. 31, 2008
2008 Senior Convertible Notes [Member]
Dec. 31, 2009
2009 Senior Convertible Notes [Member]
Dec. 31, 2012
Senior Convertible Notes [Member]
Dec. 31, 2010
Senior Convertible Notes [Member]
Dec. 31, 2010
Senior Convertible Notes [Member]
Series A [Member]
Debt (Textual) [Abstract]                                                                          
Term loan                         $ 15,000,000                                                
Received net proceeds                         14,700,000                             570,000   750,000              
Interest rate                           interest at a rate per annum equal to the greater of (i) 9.25% or (ii) 9.25% plus the sum of the prevailing prime rate minus 3.25%                                              
Loan bears interest at a rate per annum                           9.25%             8.00%             10.00%   10.00%   8.00%   8.00%      
Deduction rate on loan bears interest at a rate per annum                           3.25%                                              
Maturity Date                           Mar. 01, 2016     Sep. 30, 2010   Feb. 20, 2010                                    
Interest payment term                           interest-only payments for the initial 12 months and thereafter repay the principal balance of the loan with interest in 30 monthly installments.                                              
No of Loan repayment installments after 12 month                           30                                              
Interest only period Contingent upon achievement of certain clinical development milestone                           6 months                                              
Number of Loan repayment consists of interest installments before 12 month                           12                                              
Subsequent private placement                           2,000,000                                              
Warrant period                           7 years                                              
Warrant to purchase common stock             20,000             73,009                           27,175                  
Increase Warrants pursuant to an anti-dilution     3,371,161 10,206,543 3,498,114         1,091,558 804,949 261,860                                     40,787            
Cash Commissions percentage of gross proceeds                                                       2.00%                  
Warrant exercise price             5.72             5.65                                              
Fair value of the warrant contractual term 6 years                             7 years                                          
Fair value of the warrant volatility 104.51%                             87.20%                                          
Fair value of risk-free interest rate 1.06%                             1.10%                                          
Dividend yield 0.00%                             0.00%                                          
Approximate fair value of the warrant     14,800,000     14,800,000                 323,000                                            
Charges on termination of the loan stated percentage                           2.65%                                              
Charges on termination of the loan, amount                           398,000                                              
Fees related to the loan agreement                           218,000                                         800,000    
Interest rate for amortize loan discounts                           12.30%                                              
Interest expense related to the Hercules loan     670,000 74,000 1,535,000 3,953,000               609,000                                              
Interest expenses accretion of debt discounts                           123,000                                              
Term of debt instrument periodic payment                           12 months                                              
Current portion of note payable     1,799,000     1,799,000               1,799,000                                              
Non Current portion of notes payable     12,386,000     12,386,000                                                              
2015     6,300,000     6,300,000                                                              
2013     1,800,000     1,800,000                                                              
2014     5,750,000     5,750,000                                                              
2016     1,140,000     1,140,000                                                              
Paid off to its related party               61,000                                                          
Repaid the principal amount of accrued interest                                                         600,000                
Promissory note maturity period                                                   3 years 4 years                    
Promissory note issuance date                                         Jan. 17, 2008       Jun. 28, 2006 Jul. 30, 2007                      
Common stock conversion price equal to lowest price paid by investors                                       100.00%   7.50%                              
Debt discount recorded     815,000     815,000                             100,000                                
Qualified equity financing amount                                           10,000,000                              
Related party notes, principal and accrued interest                                   300,000     1,600,000                                
Convertible Preferred stock number of preferred stock converted into common stock                                             36,194 273,046                          
Aggregate consideration payable               20,706,000                                                          
Cash proceeds from Senior Convertible Notes                                                                   3,500,000      
Cash proceeds from 2008 Senior Convertible Notes                                                                 4,100,000        
Due date of Senior Convertible Note                                                                 Feb. 20, 2009 Feb. 20, 2010      
Extended Maturity date                                                                 Feb. 20, 2010     Sep. 30, 2010  
Increased Interest rate                                                               0.10          
Options to extended maturity period                                                                 1 year        
Interest Expense on estimated life     2 years                                                                    
Debt Discount         700,000                 939,000                                              
Repayment Premium, Percentage   42.90%                                                                      
Principal and accrued interest total                                                                         8,600,000
Senior convertible notes converted to shares                                                                         1,464,479
Share per price                 $ 5.87                           $ 8.39 $ 5.87                          
Repayment Premium                                                                         $ 600,000
Commission as percentage of gross proceeds                                                                     7.00%