Quarterly report pursuant to Section 13 or 15(d)

Collaboration Agreement (Narrative) (Details)

v3.22.2.2
Collaboration Agreement (Narrative) (Details)
$ in Thousands
3 Months Ended 9 Months Ended
Feb. 24, 2021
USD ($)
Milestone
Sep. 30, 2022
USD ($)
Sep. 30, 2021
USD ($)
Sep. 30, 2022
USD ($)
Sep. 30, 2021
USD ($)
Dec. 31, 2021
USD ($)
Collaboration revenue   $ 364 $ 1,446 $ 1,518 $ 4,646  
Accumulated deficit   (607,090)   (607,090)   $ (547,463)
Cash and cash equivalents   208,351 252,721 208,351 252,721 $ 305,744
Cyprium [Member] | Sentynl Therapeutics, Inc [Member]            
Upfront fees payment $ 8,000          
Payments of milestones $ 12,000          
Percentage of ownership over any FDA priority review voucher 100.00%          
Number of net sales milestones | Milestone 5          
Collaboration revenue   $ 400 $ 1,400 $ 1,500 $ 4,600  
FDA approval of the NDA [Member] | Cyprium [Member] | Sentynl Therapeutics, Inc [Member]            
Payments of milestones $ 9,000          
Achievement of Certain Sales Milestones [Member] | Cyprium [Member] | Sentynl Therapeutics, Inc [Member]            
Payments of milestones 255,000          
Completion of Clinical Development Milestones [Member] | Cyprium [Member] | Sentynl Therapeutics, Inc [Member]            
Payments of milestones $ 3,000