The human immune system is a complex network of special cells and organs that defends the body from germs and other foreign invaders. At the core of the immune system is the ability to tell the difference between self and non-self (your own cells and those from outside or foreign material). Autoimmune diseases arise from an overactive and misguided immune response of the body against substances and tissues normally present in the body (self). In other words, the body makes autoantibodies, and actually attacks itself. At the same time, special cells called regulatory T cells (Treg) fail to do their job of keeping the immune system in line. The resulting damage is dependent on the type of autoimmune disease. Overall, autoimmune diseases are common, affecting up to 50 million Americans. They are one of the leading causes of death and disability in this country. Coronado Biosciences is currently focused on the following autoimmune diseases but many other autoimmune diseases may be amendable to treatment with TSO.